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Registro Completo |
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Biblioteca(s): |
Embrapa Agroenergia. |
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Data corrente: |
15/03/2019 |
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Data da última atualização: |
18/11/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SANTOS, R. de C. dos; BONAMINA, F.; PÉRICO, L. L.; RODRIGUES, V. P.; ZANATTA, A. C.; RODRIGUES, C. M.; SANNOMIYA, M.; RAMOS. M. A. dos S.; BONIFÁCIO, B. V.; BAUAB, T. M.; TAMASHIRO, J.; ROCHA, L. R. M. da; VILEGAS, W.; HIRUMA-LIMA, C. A. |
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Afiliação: |
Raquel de Cássia dos Santos; Flavia Bonamina; Larissa Lucena Périco; Vinícius Peixoto Rodrigues; Ana Caroline Zanatta; CLENILSON MARTINS RODRIGUES, CNPAE; Miriam Sannomiya; Matheus Aparecido dos Santos Ramos; Bruna Vidal Bonifácio; Taís Maria Bauab; Jorge Tamashiro; Lúcia Regina Machado da Rocha; Wagner Vilegas; Clelia Akiko Hiruma-Lima. |
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Título: |
Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and antiinflammatory activities. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Biomedicine & Pharmacotherapy, v. 111, p. 1112-1123, 2019. |
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Idioma: |
Inglês |
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Conteúdo: |
Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acidinduced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin 1β (IL-1β), interleukin 10 (IL-10), and myeloperoxidase (MPO) activity and glutathione (GSH) levels were determined. The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and duodenal mucosal damage induced by cysteamine. Additionally, both partitions were associated with a significant increase in gastric and duodenal healing and increased gastric mucosal GSH content after damage induced by acetic acid. On the other hand, after 6 days of treatment, EtOAc was more effective than AcoAq in ameliorating gastric damage upon initiation of the gastric I/R, which was accompanied by a significant reduction in the activity of gastric mucosal MPO, IL 1-β and TNFalpha, as well as an elevation in IL-10 and GSH content. These results demonstrate that the oligomeric proanthocyanidins and galloyl quinic esters present in AcoAq were more effective in the prevention of gastric and duodenal ulcers due to the antioxidant effects of these compounds, whereas the flavonoids present in EtOAc were more effective due to their anti-inflammatory activity on the gastric and duodenal tissue. All these results confirm that the rich phytochemical diversity of B. intermedia contributes to the pharmacological actions of this medicinal plant on the gastrointestinal tract in addition to its activity against H. pylori. MenosByrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acidinduced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin 1β (IL-1β), interleukin 10 (IL-10), and myeloperoxidase (MPO) activity and glutathione (GSH) levels were determined. The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and duodenal mucosal damage induced by cysteamine. Additionally, bo... Mostrar Tudo |
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Palavras-Chave: |
Healing effect; Peptic ulcer. |
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Thesaurus Nal: |
Anti-inflammatory activity. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/194314/1/CLENILSON-039-Biomedicine-and-Pharmacotherapy-V.111-Issue.3-2019-1112-1123.pdf
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Marc: |
LEADER 03557naa a2200313 a 4500
001 2107125
005 2019-11-18
008 2019 bl uuuu u00u1 u #d
100 1 $aSANTOS, R. de C. dos
245 $aByrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and antiinflammatory activities.$h[electronic resource]
260 $c2019
520 $aByrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acidinduced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin 1β (IL-1β), interleukin 10 (IL-10), and myeloperoxidase (MPO) activity and glutathione (GSH) levels were determined. The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and duodenal mucosal damage induced by cysteamine. Additionally, both partitions were associated with a significant increase in gastric and duodenal healing and increased gastric mucosal GSH content after damage induced by acetic acid. On the other hand, after 6 days of treatment, EtOAc was more effective than AcoAq in ameliorating gastric damage upon initiation of the gastric I/R, which was accompanied by a significant reduction in the activity of gastric mucosal MPO, IL 1-β and TNFalpha, as well as an elevation in IL-10 and GSH content. These results demonstrate that the oligomeric proanthocyanidins and galloyl quinic esters present in AcoAq were more effective in the prevention of gastric and duodenal ulcers due to the antioxidant effects of these compounds, whereas the flavonoids present in EtOAc were more effective due to their anti-inflammatory activity on the gastric and duodenal tissue. All these results confirm that the rich phytochemical diversity of B. intermedia contributes to the pharmacological actions of this medicinal plant on the gastrointestinal tract in addition to its activity against H. pylori.
650 $aAnti-inflammatory activity
653 $aHealing effect
653 $aPeptic ulcer
700 1 $aBONAMINA, F.
700 1 $aPÉRICO, L. L.
700 1 $aRODRIGUES, V. P.
700 1 $aZANATTA, A. C.
700 1 $aRODRIGUES, C. M.
700 1 $aSANNOMIYA, M.
700 1 $aRAMOS. M. A. dos S.
700 1 $aBONIFÁCIO, B. V.
700 1 $aBAUAB, T. M.
700 1 $aTAMASHIRO, J.
700 1 $aROCHA, L. R. M. da
700 1 $aVILEGAS, W.
700 1 $aHIRUMA-LIMA, C. A.
773 $tBiomedicine & Pharmacotherapy$gv. 111, p. 1112-1123, 2019.
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Registro original: |
Embrapa Agroenergia (CNPAE) |
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Registro Completo
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
20/03/2013 |
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Data da última atualização: |
20/03/2013 |
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Tipo da produção científica: |
Artigo em Anais de Congresso |
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Autoria: |
BERGMANN, N. T.; CARDOSO, J. H.; VELASQUES, N. C.; GRINBERG, P. da S. |
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Afiliação: |
NAGILAH TESSMER BERGMANN, UFPEL; JOEL HENRIQUE CARDOSO, CPACT; NATHALIA CARDOSO VELASQUES, FURG; PATRICIA DA SILVA GRINBERG, UCPEL. |
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Título: |
Licenciamento de espécies florestais nativas em sistemas agroflorestais no contexto da agricultura familiar. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
In: SEMINÁRIO INTERNACIONAL DE EDUCAÇÃO E PESQUISA EM ECOLOGIA, 3., 2012, Pelotas, RS. Anais... Pelotas: Universidade Católica de Pelotas, 2012. |
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Idioma: |
Português |
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Conteúdo: |
O estudo está sendo realizado em três agroecossistemas que participam do projeto de pesquisa ?Construção participativa de sistemas agroflorestais no território sul do Rio Grande do Sul ? Encosta da Serra do Sudeste?, onde foram implantadas unidades pedagógicas de sistemas agroflorestais (SAFs). O presente trabalho consiste em exercitar o processo de licenciamento de plantios florestais com espécies nativas. Para tanto, tem-se realizado revisão bibliográfica e de fontes secundárias, entrevistas com os agentes licenciadores e famílias agricultoras, com o intuito de esclarecer, problematizar e qualificar os procedimentos administrativos e legais para que um agricultor possa plantar, manejar e colher produtos madeireiros e não-madeireiros, oriundos de espécies florestais nativas, atendendo as exigências da legislação ambiental. Abstract The study was conducted in three agroecosystems that participate in the research project "construction development of agroforestry systems in the territory south of the Rio Grande do Sul - South East Side of the Sierra," where units were deployed teaching agroforestry systems (AFS). The present work consists in exercising the licensing process forest plantations with native species. For both, we have performed bibliographic review and secondary sources, interviews with the licensors and farming families, with the intention of clarify, problematize and qualify the administrative and legal procedures necessary for that a farmer to plant, manage and harvest timber and non-wood from native forest species, meeting the requirement of environmental legislation. MenosO estudo está sendo realizado em três agroecossistemas que participam do projeto de pesquisa ?Construção participativa de sistemas agroflorestais no território sul do Rio Grande do Sul ? Encosta da Serra do Sudeste?, onde foram implantadas unidades pedagógicas de sistemas agroflorestais (SAFs). O presente trabalho consiste em exercitar o processo de licenciamento de plantios florestais com espécies nativas. Para tanto, tem-se realizado revisão bibliográfica e de fontes secundárias, entrevistas com os agentes licenciadores e famílias agricultoras, com o intuito de esclarecer, problematizar e qualificar os procedimentos administrativos e legais para que um agricultor possa plantar, manejar e colher produtos madeireiros e não-madeireiros, oriundos de espécies florestais nativas, atendendo as exigências da legislação ambiental. Abstract The study was conducted in three agroecosystems that participate in the research project "construction development of agroforestry systems in the territory south of the Rio Grande do Sul - South East Side of the Sierra," where units were deployed teaching agroforestry systems (AFS). The present work consists in exercising the licensing process forest plantations with native species. For both, we have performed bibliographic review and secondary sources, interviews with the licensors and farming families, with the intention of clarify, problematize and qualify the administrative and legal procedures necessary for that a farmer to plant, manage and... Mostrar Tudo |
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Palavras-Chave: |
Licenciamento ambiental; Sistema Agroflorestal. |
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Thesagro: |
Agricultura Familiar. |
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Categoria do assunto: |
K Ciência Florestal e Produtos de Origem Vegetal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/79455/1/0000005487-LICENCIAMENTO-DE-ESPECIES-FLORESTAIS-NATIVAS-EM-SISTEMAS-AGROFLORESTAIS-NO-CONTEXTO-DA-AGRICULTUR.pdf
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Marc: |
LEADER 02323nam a2200181 a 4500
001 1953562
005 2013-03-20
008 2012 bl uuuu u00u1 u #d
100 1 $aBERGMANN, N. T.
245 $aLicenciamento de espécies florestais nativas em sistemas agroflorestais no contexto da agricultura familiar.$h[electronic resource]
260 $aIn: SEMINÁRIO INTERNACIONAL DE EDUCAÇÃO E PESQUISA EM ECOLOGIA, 3., 2012, Pelotas, RS. Anais... Pelotas: Universidade Católica de Pelotas$c2012
520 $aO estudo está sendo realizado em três agroecossistemas que participam do projeto de pesquisa ?Construção participativa de sistemas agroflorestais no território sul do Rio Grande do Sul ? Encosta da Serra do Sudeste?, onde foram implantadas unidades pedagógicas de sistemas agroflorestais (SAFs). O presente trabalho consiste em exercitar o processo de licenciamento de plantios florestais com espécies nativas. Para tanto, tem-se realizado revisão bibliográfica e de fontes secundárias, entrevistas com os agentes licenciadores e famílias agricultoras, com o intuito de esclarecer, problematizar e qualificar os procedimentos administrativos e legais para que um agricultor possa plantar, manejar e colher produtos madeireiros e não-madeireiros, oriundos de espécies florestais nativas, atendendo as exigências da legislação ambiental. Abstract The study was conducted in three agroecosystems that participate in the research project "construction development of agroforestry systems in the territory south of the Rio Grande do Sul - South East Side of the Sierra," where units were deployed teaching agroforestry systems (AFS). The present work consists in exercising the licensing process forest plantations with native species. For both, we have performed bibliographic review and secondary sources, interviews with the licensors and farming families, with the intention of clarify, problematize and qualify the administrative and legal procedures necessary for that a farmer to plant, manage and harvest timber and non-wood from native forest species, meeting the requirement of environmental legislation.
650 $aAgricultura Familiar
653 $aLicenciamento ambiental
653 $aSistema Agroflorestal
700 1 $aCARDOSO, J. H.
700 1 $aVELASQUES, N. C.
700 1 $aGRINBERG, P. da S.
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